BRIEF RESEARCH COMMUNICATION Suggestive Synergy Between Genetic Variants in TF and HFE as Risk Factors for Alzheimer’s Disease
نویسندگان
چکیده
Suggestive Synergy Between Genetic Variants in TF and HFE as Risk Factors for Alzheimer’s Disease J.S.K. Kauwe, S. Bertelsen, K. Mayo, C. Cruchaga, R. Abraham, P. Hollingworth, D. Harold, M.J. Owen, J. Williams, S. Lovestone, J.C. Morris, A.M. Goate* and the Alzheimer’s Disease Neuroimaging Initiative Department of Psychiatry & Neurology, Washington University School of Medicine, St. Louis, Missouri Department of Psychological Medicine, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK Department of Neuroscience, Institute of Psychiatry, Kings College, London, UK
منابع مشابه
Synergy between the C2 allele of transferrin and the C282Y allele of the haemochromatosis gene (HFE) as risk factors for developing Alzheimer's disease.
BACKGROUND There is evidence that iron may play a role in the pathology of Alzheimer's disease (AD). There may be genetic factors that contribute to iron deposition resulting in tissue damage thus exacerbating AD. METHODS We have genotyped 269 healthy elderly controls, 191 cases with definite or probable AD, and 69 with mild cognitive impairment (MCI) from the OPTIMA cohort. RESULTS We have...
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